The correlation between plasma homocysteine and malondialdehyde levels in preeclampsia.
نویسندگان
چکیده
OBJECTIVE To investigate the possible correlation between plasma malondialdehyde and homocysteine levels of preeclamptic patients. DESIGN Venous blood samples of 20 preeclamptics and 20 healthy pregnant controls were collected. Plasma malondialdehyde and homocysteine concentrations were measured and the correlation between them was investigated. Mann Whitney U test and Spearman correlation analysis were used for statistical analysis. SETTING University of Firat, Medical School. RESULTS Plasma malondialdehyde and homocysteine concentrations were higher in preeclamptic patients (p<0.05) and a positive correlation between these parameters was found (r: 0.77, p<0.01, n:20). CONCLUSION Our results may put forward some new strategies in the research of etiopathogenesis and treatment of preeclampsia.
منابع مشابه
آیا سطح هموسیستئین پلاسما در بیماران دیابت ملیتوس تیپ II با افراد مبتلا به اختلال تحمل گلوکز و افراد طبیعی تفاوت دارد؟
Introduction: Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease in diabetic patients. The aim of this study was to determine plasma homocysteine levels in diabetics and compare with control persons and also evaluation of correlation between plasma homocysteine concentration and diabetic related variables. Methods: This study was done on 39 type II diabetic pa...
متن کاملبررسی ارتباط میزان سطوح سرمی بیومارکرهای استرس اکسیداتیو و پره اکلامپسی
Background : Preeclampsia is a major cause of maternal and perinatal morbidity and mortality. The aim of the present study was to assess serum levels of isoprostane F2α, malondialdehyde and total homocysteine in preeclamptic women compared with normal pregnant women. Materials and Methods: A cross-sectional study was designed. The patients consisted of 30 preeclamptic women. The normal group c...
متن کاملبررسی مقایسه‌ای سطح خونی هموسیستئین و اسید فولیک و ویتامین B12 در خانم‌های باردار نرمال و پره‌اکلامپسی شدید
Background & Aims: Preeclampsia complicates 5 to 10 percent of all pregnancies that contribute greatly to maternal morbidity and mortality rates. Although homocysteine is a necessary amino acid to maintain cell growing and developing but at the serum levels above normal is a risk factor for some endothelial damages and thrombosis inside blood vessels. In the present study, we investigated the ...
متن کاملرابطه بین هموسیستیین پلاسما و فشار خون در بیماران مبتلا به دیابت نوع دو
Background: Hyperhomocysteinemia may increase blood pressure by inducing endothelial cells dysfunction . The aim of this study was determining the relationship between plasma Homocysteine (Hcy) levels and blood pressure in new cases of type 2 diabetes mellitus.Methods: As a cross sectional study, 46 new cases of type 2 diabetes mellitus referred to Isfahan Endocrine and Metabolism Research Cent...
متن کاملبررسی سطح هموسیستئین پلاسما در بیماران دیابتی نوع 2 تحت درمان با متفورمین و ارتباط آن با ظرفیت تام آنتی‌اکسیدانی، مالون دی آلدهید، کراتی‌نین سرم، مقاومت انسولینی و کنترل گلایسمیک
Background and Objective: In patients with diabetes, elevated homocysteine levels have been reported to be associated with endothelial dysfunction, insulin resistance, dyslipidemia, poor control of disease, nephropathy, macroangiopathy and oxidative stress. Thus, this observational study was performed to determine the plasma homocysteine level and its correlation with clinical, biochemical and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuro endocrinology letters
دوره 24 6 شماره
صفحات -
تاریخ انتشار 2003